Jabwise

Do side effects ease over time?

Usually, the leaflets say, for the stomach ones. Mounjaro’s says feeling sick, diarrhoea and being sick decrease over time in most patients. Ozempic’s and Rybelsus’s say feeling sick and diarrhoea usually go away over time, and Wegovy’s says so of its very common side effects. None gives a timescale.

An illustration of the leaflets’ wording

In their own words

Which side effects each leaflet says usually ease, in its own words.

MedicineSide effectsWhat it says
MounjaroFeeling sick, diarrhoea, being sickThey are most common when first starting tirzepatide but decrease over time in most patients.Mounjaro KwikPen patient leaflet
WegovyHeadache, feeling or being sick, diarrhoea, constipation, stomach pain, feeling weak or tiredThese usually go away over time.Wegovy FlexTouch patient leaflet
OzempicFeeling sick, diarrhoeathis usually goes away over timeOzempic patient leaflet
RybelsusFeeling sick, diarrhoeathis usually goes away over timeRybelsus 3, 7 and 14mg patient leaflet

Meanwhile

  • On stopping

    The NHS says keep taking your medicine unless you’re advised to stop, and talk to your doctor if you want to stop.

  • If one bothers you

    If a side effect bothers you or doesn’t go away, the NHS says a pharmacist or doctor may give advice on how to reduce it.

  • Usually not severe

    Mounjaro’s leaflet says feeling sick, diarrhoea and being sick are usually not severe, and decrease over time for most.

  • Fluids

    The Mounjaro, Wegovy, Ozempic and Rybelsus leaflets say these can dehydrate you, so drink fluids to prevent it.

Questions

How long until they ease?

The leaflets don’t say. Mounjaro’s says they are most common when first starting; the others say they usually go away over time.

What if one doesn’t go away?

The NHS says speak to a pharmacist or doctor if you have any side effects that bother you or do not go away.

Which ones need help straight away?

The NHS lists serious ones, such as an inflamed pancreas, which can cause severe pain in your stomach or back that does not go away, and says call 111 if you think you might be having one. Our side effects guide has the list.

Side effects

See whether a side effect is easing.

Each check-in asks “Any side effects currently?” Side Effects counts the days you felt each one over 7, 30 or 90 days, so you can compare a recent week with the month.

Jabwise Side Effects: constipation on 2 of 6 days with a check-in, over the last 7 days

Sources

General information, not medical advice. Follow your prescriber’s guidance.

Getting real advice

We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.

  • Quoted from official sources, each one linked
  • Sources checked 12 October 2026
  • No dosing advice; your prescriber comes first