Jabwise

Constipation on a GLP-1

All four list it, and so do both NHS pages. Wegovy’s leaflet calls it very common, as does Mounjaro’s for weight management; Ozempic’s calls it common. In two Zepbound trials, 11% to 17% reported it, against 5% on placebo. Wegovy’s and Ozempic’s list bowel obstruction; Zepbound’s, intestinal obstruction.

5%Placebo17%5mg14%10mg11%15mg

Reported constipation in Zepbound’s trials

How common it is

Each source’s own words for how common constipation is, quoted as written. Zepbound’s label counts it among its most common side effects.

MedicineHow common
MounjaroConstipation is very common in patients treated for weight management, and in the type 2 diabetes cardiovascular disease study but common in patients treated for type 2 diabetes.Mounjaro KwikPen patient leaflet
ZepboundThe most common adverse reactions, reported in ≥5% of patients treated with ZEPBOUNDZepbound prescribing information
WegovyVery common: may affect more than 1 in 10 peopleWegovy FlexTouch patient leaflet
OzempicCommon (may affect up to 1 in 10 people)Ozempic patient leaflet

What else they say

  • It often eases

    Wegovy’s leaflet lists constipation with its very common side effects, and says these usually go away over time.

  • By dose in the trials

    In Zepbound’s trials, constipation was reported by 17% on 5mg, 14% on 10mg and 11% on 15mg, against 5% on placebo.

  • A severe form

    Wegovy and Ozempic list bowel obstruction, a severe form. Zepbound’s label lists intestinal obstruction after approval.

  • If it bothers you

    If a side effect bothers you or doesn’t go away, the NHS says a pharmacist or doctor may give advice on how to reduce it.

Questions

Is constipation a side effect of Mounjaro?

Yes. Mounjaro’s leaflet says it’s very common in people treated for weight management and in a heart study of people with type 2 diabetes, and common in people treated for type 2 diabetes.

Does it go away?

Wegovy’s leaflet says its very common side effects, constipation among them, usually go away over time. The other leaflets don’t say so for constipation.

When is it serious?

Wegovy’s and Ozempic’s leaflets list bowel obstruction, a severe form of constipation with stomach ache, bloating or vomiting. Zepbound’s label lists intestinal obstruction and severe constipation reported after approval. If you think you’re having a serious side effect, the NHS says call 111.

Side effects

Count the days it’s there.

Each check-in asks “Any side effects currently?”, and Constipation is one tap. Side Effects counts the days you felt it, over 7, 30 or 90 days, ready for your next review.

Jabwise Side Effects: constipation on 2 of 6 days with a check-in, over the last 7 days

Sources

General information, not medical advice. Follow your prescriber’s guidance.

Getting real advice

We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.

  • Quoted from official sources, each one linked
  • Sources checked 12 October 2026
  • No dosing advice; your prescriber comes first