# Heartburn, burping and indigestion

> All four list them. Mounjaro’s, Wegovy’s and Ozempic’s leaflets each call indigestion, burping and reflux or heartburn common, up to 1 in 10 people. In two Zepbound trials, indigestion was reported by 9% to 10% of people on it, against 4% on placebo, and reflux and burping by 4% to 5%.

Canonical: https://jabwise.app/guides/heartburn-and-burping. Sources checked 12 October 2026. General information, not medical advice: follow your prescriber.

## In their own words

Each source’s own name for them, quoted as written. Mounjaro’s, Wegovy’s and Ozempic’s leaflets list all three as common side effects.

- **Mounjaro**: Indigestion: "Indigestion (dyspepsia)" ([Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil)); Burping: "Burping (eructation)" ([Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil)); Reflux or heartburn: "Reflux or heartburn (also called gastroesophageal reflux disease – GORD)" ([Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil))
- **Zepbound**: Indigestion: "indigestion" ([Zepbound prescribing information](https://uspl.lilly.com/zepbound/zepbound.html)); Burping: "belching" ([Zepbound prescribing information](https://uspl.lilly.com/zepbound/zepbound.html)); Reflux or heartburn: "heartburn" ([Zepbound prescribing information](https://uspl.lilly.com/zepbound/zepbound.html))
- **Wegovy**: Indigestion: "upset stomach or indigestion" ([Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil)); Burping: "burping" ([Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil)); Reflux or heartburn: "reflux or heartburn – also called ‘gastro-oesophageal reflux disease’" ([Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil))
- **Ozempic**: Indigestion: "Indigestion" ([Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil)); Burping: "Burping" ([Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil)); Reflux or heartburn: "Reflux or heartburn – also called ‘gastro-esophageal reflux disease’ (GERD)" ([Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil))

## What else they say

- **What reflux is**: Mounjaro’s leaflet says reflux is caused by stomach acid coming up into the tube from your stomach to your mouth.
- **An inflamed stomach**: Wegovy and Ozempic also list gastritis, an inflamed stomach, with signs like stomach ache, feeling sick or being sick.
- **In Zepbound’s trials**: Indigestion was reported by 9% to 10% on Zepbound, against 4% on placebo; burping by 4% to 5%, against 1%.
- **If one bothers you**: Zepbound’s label says talk to your healthcare provider if you have any side effect that bothers you or does not go away.

## Questions

### Does Mounjaro cause heartburn?

Its leaflet lists reflux or heartburn as common, up to 1 in 10 people, along with indigestion and burping.

### Is burping a side effect of Ozempic?

Yes. Ozempic’s leaflet lists burping as common, up to 1 in 10 people. Mounjaro’s and Wegovy’s leaflets list it too, and Zepbound’s label calls it belching.

### What helps?

None of these leaflets suggests a remedy. The NHS says speak to a pharmacist or doctor if a side effect bothers you or doesn’t go away; they may be able to give advice.

## In Jabwise: Side effects

Count the days heartburn is there. The check-in has a tag for heartburn. Side Effects counts the days you felt it, over 7, 30 or 90 days, ready for your next review.

## Getting real advice

- **A pharmacist, your doctor or NHS 111**: If you’re not sure how to use your medicine, or a side effect bothers you or won’t go away. NHS 111 if you think you might be having serious side effects, or you’ve used too much. [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/), [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/), [NHS 111 online](https://111.nhs.uk/)
- **Report a side effect**: Anyone can, not only doctors. [Yellow Card (UK)](https://yellowcard.mhra.gov.uk/), [MedWatch (US)](https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program)

## Sources

- [Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil)
- [Zepbound prescribing information](https://uspl.lilly.com/zepbound/zepbound.html)
- [Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil)
- [Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil)
- [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)
- [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)