# Do side effects ease over time?

> Usually, the leaflets say, for the stomach ones. Mounjaro’s says feeling sick, diarrhoea and being sick decrease over time in most patients. Ozempic’s and Rybelsus’s say feeling sick and diarrhoea usually go away over time, and Wegovy’s says so of its very common side effects. None gives a timescale.

Canonical: https://jabwise.app/guides/do-side-effects-ease. Sources checked 12 October 2026. General information, not medical advice: follow your prescriber.

## In their own words

Which side effects each leaflet says usually ease, in its own words.

- **Mounjaro**: Side effects: Feeling sick, diarrhoea, being sick; What it says: "They are most common when first starting tirzepatide but decrease over time in most patients." ([Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil))
- **Wegovy**: Side effects: Headache, feeling or being sick, diarrhoea, constipation, stomach pain, feeling weak or tired; What it says: "These usually go away over time." ([Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil))
- **Ozempic**: Side effects: Feeling sick, diarrhoea; What it says: "this usually goes away over time" ([Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil))
- **Rybelsus**: Side effects: Feeling sick, diarrhoea; What it says: "this usually goes away over time" ([Rybelsus 3, 7 and 14mg patient leaflet](https://www.medicines.org.uk/emc/product/11507/pil))

## Meanwhile

- **On stopping**: The NHS says keep taking your medicine unless you’re advised to stop, and talk to your doctor if you want to stop.
- **If one bothers you**: If a side effect bothers you or doesn’t go away, the NHS says a pharmacist or doctor may give advice on how to reduce it.
- **Usually not severe**: Mounjaro’s leaflet says feeling sick, diarrhoea and being sick are usually not severe, and decrease over time for most.
- **Fluids**: The Mounjaro, Wegovy, Ozempic and Rybelsus leaflets say these can dehydrate you, so drink fluids to prevent it.

## Questions

### How long until they ease?

The leaflets don’t say. Mounjaro’s says they are most common when first starting; the others say they usually go away over time.

### What if one doesn’t go away?

The NHS says speak to a pharmacist or doctor if you have any side effects that bother you or do not go away.

### Which ones need help straight away?

The NHS lists serious ones, such as an inflamed pancreas, which can cause severe pain in your stomach or back that does not go away, and says call 111 if you think you might be having one. Our side effects guide has the list.

## In Jabwise: Side effects

See whether a side effect is easing. Each check-in asks “Any side effects currently?” Side Effects counts the days you felt each one over 7, 30 or 90 days, so you can compare a recent week with the month.

## Getting real advice

- **A pharmacist, your doctor or NHS 111**: If you’re not sure how to use your medicine, or a side effect bothers you or won’t go away. NHS 111 if you think you might be having serious side effects, or you’ve used too much. [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/), [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/), [NHS 111 online](https://111.nhs.uk/)
- **Report a side effect**: Anyone can, not only doctors. [Yellow Card (UK)](https://yellowcard.mhra.gov.uk/), [MedWatch (US)](https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program)

## Sources

- [Mounjaro KwikPen patient leaflet](https://www.medicines.org.uk/emc/product/15481/pil)
- [Wegovy FlexTouch patient leaflet](https://www.medicines.org.uk/emc/product/13800/pil)
- [Ozempic patient leaflet](https://www.medicines.org.uk/emc/product/9748/pil)
- [Rybelsus 3, 7 and 14mg patient leaflet](https://www.medicines.org.uk/emc/product/11507/pil)
- [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)
- [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)