# Common side effects, and when to get help > Feeling or being sick, constipation, diarrhoea, tiredness, hair loss and itchy or red skin where you inject are on the NHS lists for semaglutide and tirzepatide. Its advice is short: speak to a pharmacist or doctor if one bothers you or doesn’t go away, and keep taking your medicine unless you’re advised to stop. Canonical: https://jabwise.app/guides/common-side-effects. Sources checked 12 October 2026. General information, not medical advice: follow your prescriber. ## The common ones Semaglutide is the medicine in Wegovy and Ozempic; tirzepatide is the one in Mounjaro and Zepbound. Each cell quotes the NHS page for that medicine. - **Feeling or being sick**: Semaglutide: "feeling sick (nausea) and being sick (vomiting)" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "feeling sick (nausea) or being sick (vomiting)" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Constipation**: Semaglutide: "constipation" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "constipation or diarrhoea" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Diarrhoea**: Semaglutide: "diarrhoea" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "constipation or diarrhoea" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Stomach pain**: Semaglutide: Not on the list; Tirzepatide: "stomach pain" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Tiredness**: Semaglutide: "feeling tired" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "feeling tired" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Skin where you inject**: Semaglutide: "itchy or red skin where you inject" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "itchy or red skin where you inject" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) - **Hair loss**: Semaglutide: "hair loss" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Tirzepatide: "hair loss" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)) ## What the NHS says to do - **If one bothers you**: If a side effect bothers you or doesn’t go away, the NHS says a pharmacist or doctor may give advice on how to reduce it. - **On stopping**: Unless you’re advised to stop, the NHS says keep taking it. If you want to stop, talk to your doctor; don’t stop suddenly. - **Alcohol**: The NHS says it’s best not to drink alcohol, because it can increase side effects like feeling sick or being sick. - **Dizzy, or vision problems**: If you feel dizzy or have vision problems, the NHS says don’t drive, ride a bike or use machinery until they’ve gone. ## Rarer, and serious The NHS says most are rare, and to call 111 if you think you’re having one. - **Allergic reaction (anaphylaxis)**: As the NHS describes it: "symptoms such as a swollen throat or tongue, a raised, itchy rash or difficulty breathing" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Listed for: Both - **An inflamed pancreas**: As the NHS describes it: "severe pain in your stomach or back, which does not go away" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)); Listed for: Both - **Low blood sugar**: As the NHS describes it: "more likely if used with other diabetes medicines" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)); Listed for: Both - **Gallstones or a swollen gallbladder**: As the NHS describes it: "severe tummy pain" ([NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/)); Listed for: Tirzepatide - **Eye changes**: As the NHS describes it: "sudden loss of vision, usually in one eye at a time" ([NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/)); Listed for: Semaglutide ## Questions ### Are these all the side effects? No. The NHS says these are not all of them, and points you to the leaflet that comes with your medicine for the full list. ### Should I stop if I get side effects? The NHS says to keep taking your medicine unless you’re advised to stop, and to talk to your doctor if you want to stop rather than stopping suddenly. ### How do I report a side effect? In the UK, on the Yellow Card website, which both NHS pages link to. Anyone can report, not only doctors. In the US, the FDA’s MedWatch takes reports from the public. ## In Jabwise: Side effects Jabwise keeps your side effects in one place. Each check-in asks “Any side effects currently?”, a tap per answer. Side Effects then counts the days you felt each one, over 7, 30 or 90 days, ready for your next review. ## Getting real advice - **A pharmacist, your doctor or NHS 111**: If you’re not sure how to use your medicine, or a side effect bothers you or won’t go away. NHS 111 if you think you might be having serious side effects, or you’ve used too much. [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/), [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/), [NHS 111 online](https://111.nhs.uk/) - **Report a side effect**: Anyone can, not only doctors. [Yellow Card (UK)](https://yellowcard.mhra.gov.uk/), [MedWatch (US)](https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program) ## Sources - [NHS: Semaglutide](https://www.nhs.uk/medicines/semaglutide/) - [NHS: Tirzepatide](https://www.nhs.uk/medicines/tirzepatide/) - [Yellow Card (UK)](https://yellowcard.mhra.gov.uk/) - [MedWatch (US)](https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program)